Comprehensive clinical studies carried out confirm the effect of taking Innovabio Collagen Drinks and highlight exciting new benefits on Joint health.
Cartilage consists of a single cell type, chondrocytes embedded in extracellular matrix made up of two major components: type II collagen which imparts tensile strength to the tissue and aggrecan that provides the ability of cartilage to resist compressive force. Orchestrated synthesis and turnover ensures and maintains the biochemical
characteristic of the cartilage. During osteoarthritis, the most common form
of arthritis, this regulation is disrupted by the expression of pro-inflammatory molecules that provides the stimulus for the synthesis of matrix-degrading enzymes. These enzymes degrade aggrecan and collagen, resulting in the loss of cartilage and function.
This chronic degeneration of the joints is already considered by the World Health Organization as one of the ten most disabling diseases in developed countries. For those who are affected, the consequences are important because 80% have limitations in movement, and 25% can not perform their major daily activities of life.
All joints can be affected, although it occurs more often on knee and hip joints and in the
vertebral column. In advanced stages it is extremely painful. Osteoarthritis is usually due to the aging process, but osteoarthritis due to external factors has also been reported, for example in people whose activities involve joint stress, such as sports activities or even at work. Severe overweight can also cause osteoarthritis.
According to worldwide estimation, arthritis affects 9.6% of men and 18% of women aged over 60 years. Moreover, according to Datamonitor (2009), the arthritis prevalence has increased all over the world since 2003, such as in India (+2.3% per year) or Brazil (+2.1% per year), and will continue to grow, possibly even reaching 2.5% per year in India and 2.3% per year in Brazil.
Results
Collagen peptides is accumulated in cartilage
The beneficial effect of Collagen peptides on joint health has frequently been reported in scientific studies.
The clinical study reported by Moskowitz (8), performed on various populations for a period ranging from 30 to 90 days, demonstrated a positive effect on pain reduction with a dose of 10g of Collagen peptides per day. The effect was even more pronounced in patients suffering more severe symptoms.
Collagen peptides induces the production of type II collagen by chondrocytes
Another more recent study assessed the efficacy Collagen peptides in a randomized, double blind, controlled multicenter trial, in which 250 subjects with primary osteoarthritis of the knee were given 10g of Collagen pepetides daily for 6 months. The results showed a significant improvement in knee joint comfort, and once again subjects with the greatest joint deterioration benefited most (9).
The effectiveness of Collagen peptides has also been proven in athletes with activity-related joint pain. In a 24-week study conducted in 2008, 147 subjects who competed on a varsity team or a club sport were recruited, and were randomly assigned to two groups: a group receiving a liquid with 10g of Collagen peptides, and another group receiving a placebo. At the end of the study, participants’assessment and physicians’ measurements showed statistically significant changes with the dietary supplement Collagen peptides: the joint pain at rest, when walking, standing or carrying objects was reduced (10).
Mechanism of action
Collagen peptides is accumulated in cartilage
Some explanations for this positive effect have been revealed in the study of Oesser (11). He showed that more than 90% of the orally administered 14C labelled Collagen peptides is absorbed, and also that an important part is accumulated in the cartilage of mice as early as 12 hours after ingestion. The measured radioactivity was more than twice as high in cartilage following 14C labelled Collagen pepetides administration compared to the control group (14C labelled proline)
Collagen peptides induces the production of type II collagen by chondrocytes
In another study (12), the same author explains that the chondrocytes – cells of the cartilage – are sensitive to the products present in the extracellular matrix around them, and that the
treatment of chondrocytes with Hydrolyzed Collagen in the medium leads to a dose-dependent production of collagen by those cells.
Conclusion
The action of Collagen peptides on the joints has been demonstrated:
• Collagen peptides significantly reduces joint pain and the subjects with the greater deterioration benefit from it more.
• Orally administered Collagen peptides is accumulated in cartilage as early as 12 hours after ingestion and the cells of the joint, the chondrocytes, respond to this extracellular collagen by a dose-dependent production of endogenous collagen.
References
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