Comprehensive clinical studies carried out confirm the effect of taking Innovabio Collagen Drinks and highlight exciting new benefits on Bone health.
When bone is functioning well, there is a constant turnover of tissue ensuring that the bone is strong. In osteoporosis, however, an imbalance exists between bone formation and bone resorption, resulting in a net loss of bone mass and a structural deterioration of bone tissue.
There is actually no typical form of osteoporosis; much depends on the cause, and the gender and age of the person. However, two main types of osteoporosis have been identified:
• Primary osteoporosis (or type I osteoporosis) is known as the post-menopausal osteoporosis and is caused by the drastic reduction in oestrogen level subsequent to menopause. These hormones exert an influence on other hormone systems that are involved in bone metabolism.
• Secondary osteoporosis (or type II osteoporosis) is known as the senile osteoporosis. It occurs in older men and women, usually after the age of 70, and it can be due to inactivity.
According to the World Health Organization, 15% of those aged 50 – 59 years old, and 70% of those over 80, suffer from this bone deterioration; most often leading to fractures of the hip, spine, and wrist. Hip fracture, the commonest of these, regularly requires hospitalization. It is fatal in 20% of cases, and permanently disables a further 50% and only 30% recover fully. According to Datamonitor (2009), the prevalence of osteoporosis has increased
worldwide since 2003, such as in the USA (+2.5% per year) or India (+1.9% per year), and will continue to grow.
Collagen, which represents 90% of the organic mass of the bone, has been identified as efficient in the prevention of bone diseases. Indeed, several studies have shown that a daily intake of 10g per day of Collagen peptides for 4 to 24 weeks increases bone mineral density (1, 2). Researchers have shed some light on the mechanism of action of Collagen peptides, and have shown that the extracellular matrix in which cells grow is determinant for their differentiation. They have demonstrated that when Collagen peptides metabolites are present in this matrix, osteoblasts, the cells responsible for bone formation are preferentially stimulated, instead of osteoclasts, the cells involved in bone resorption: this triggers bone formation (4, 5, 6).
Studies conducted at the Laboratory of Physiology and Ingestive Behavior, INRA-AgroParis Tech (Paris, France), and presented hereafter, confirm these scientific results and provide new information about the effect of Collagen Peptides on bone metabolism (7).
Results
In Vitro Results
Collagen induces the differentiation of cells into osteoblasts
In mixed culture of osteoblasts and osteoclasts, the levels of alkaline phosphatase (ALP), a marker of bone formation,are increased when Collagen peptides is present in the media. Since the number of cells does not increase with Collagen peptides compared to the control, that means that Collagen induces the differentiation of cells into osteoblasts rather than osteoclasts.
Collagen reduces bone resorption
Moreover, when the culture is performed on a system which allows measurement of osteoclast-mediated bone resorption for 14 days, we can see that in presence of Collagen, the resorption area is reduced compared to the control.
In Vivo Results
Colalgen restores bone mineral density
The in vivo part of this study confirms but also reveals some new results. In this part, variectomized mice were used to simulate a postmenopausal osteoporosis. This surgery actually slows down the bone mineral density increase in the growth mice concerned, resulting in a lower bone mineral density than in non ovariectomized mice, as it is the case in osteoporosis.
The mice were then fed with or without Collagen peptides during 12 weeks, and various data were collected. The Collagen group consumed 4g daily of a diet containing 2.5% of Collagen.
First, in ovariectomized mice fed with Collagen during 12 weeks, measures show restoration of the bone mineral density value close to the level of the control group (not ovariectomized).
Collagen increases the size and solidity
Moreover, growth of the cortical zone (external area of the bone) of the femur, and a consequent increase in bone size, has beenmeasured in ovariectomized mice fed Collagen, compared to ovariectomized mice fed without Collagen. Due to this restoration, the ultimate strength of the bones (strength required to lead to a break) was significantly greater for ovariectomized mice which had taken Collagen.
Collagen decreases the bone resorption
Finally, confirming in vitro studies, in vivo studies have demonstrated that the bone resorption of ovariectomized mice fed with Collagen , measured by CTX production, is similar to the non ovariectomized mice.
Conclusion
Collagen peptides has demonstrated its efficacy on bone metabolism. Collagen induces differentiation and maturation of osteoblast and stimulates their activity. Bone turnover is thus modulated so preventing bone resorption during the natural phenomenon of menopause and increasing bone solidity.
References
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